Jeffrey P. Spafford ’88

Headshot of Jeffrey P. Spafford ’88

Jeff Spafford ’88 has more than 25 years of wide-ranging healthcare executive leadership, including roles that have guided sales, marketing, strategy, and technology innovation. In 2009, after 10+ years as a specialty pharmacy owner and innovator, Jeff realized the need for a technology-driven process to simplify a complex system, improve specialty patients’ speed to therapy and drive better outcomes from care. He co-founded AssistRx, and has served as president and CEO since its inception. AssistRx is the market’s leading specialty therapy initiation and patient support company with a mission to transform lives through access to therapy. As a key driver of AssistRx’s strategic vision and organizational growth, Jeff was named CEO of the Year by Orlando Business Journal in 2016. Additionally, AssistRx was selected as one of Orlando’s top workplaces in 2021 by Orlando Sentinel Media Group. 

Through his continued work to support medication access and therapy affordability for patients, Jeff co-founded The Assistance Fund — a non-profit created to help patients and families facing high medical costs by providing financial assistance for co-payments, co-insurance and related medical expenses. The Assistance Fund was on Forbes’ list of the 100 largest U.S. charities in 2021. Jeff also serves on the board of directors for etectRx — a digital health start-up aimed at embedding wireless sensors into medications to support patient adherence therapy.

In 1998, Jeff established OncoScripts, one of the first specialty pharmacies in the nation. After OncoScripts was acquired in 2001 by CuraScript, he served as executive vice president of sales and marketing until 2005 when he co-founded Advanced Care Scripts (ACS). Serving as president and CEO, he built ACS into a leading specialty pharmacy and pharma services organization. After three years of rapid growth, he sold and shifted management of the business to Omnicare, Inc.

Jeff began his career with the General Electric Company as part of the Financial Management Program. Upon finishing the program, he earned a Master of Business Administration from Harvard Business School and took a leadership position with APM, Inc. where he focused on management consulting for large hospital systems and independent healthcare practices.

Spafford holds a bachelor’s degree in economics from St. Lawrence University where he earned Phi Beta Kappa honors. He has been a strong voice for St. Lawrence students looking to make an impact in the world. He returned to his alma mater in 2018 as a Laurentian in Residence, spending time with students both in and out of the classroom. He also has served as a career advisor and is a loyal supporter of the St. Lawrence Fund. Most recently, Jeff supported Learning for the 21st Century initiatives during The Campaign for Every Laurentian.

Jeff resides in the Central Florida area with his wife Amy and their four children.