Associate Professor Chemistry
Johnson Hall of Science email@example.com | (315) 229-5859
general chemistry, quantitative analysis, bio-analyticalchemistry, instrumental analysis, environmental chemistry, and biochemistry.
- Protein folding. Understanding the mechanism by whichproteins acquire their precisely folded three-dimensional structures remainsone of the most important challenges of structural biology. To solve thiscomplex problem, a variety of experimental techniques as well as computationalmethods of analysis are used to probe the role of different interactions inprotein folding and protein interactions with ligands. Answers to theprotein-folding problem play a key role in designing proteins with newfunctional properties and improved methods for protein structure prediction.Moreover, a thorough understanding of the principles that govern folding ofproteins in vitro is a prerequisite for elucidating protein folding in thecell, which has far-reaching biological and medical implications.
- Medicinally relevant alkaloids. Current research is focusedon the development, validation, and application of HPLC methods to test formedicinally relevant pharmaceutical products in ethnopharmaceuticals. Currentresearch collaboration with Dr. Aswini Pai in biology include assessing theconcentration of isoquinoline alkaloids in Hydrastis canadensis.
- Androgen Receptor. In mammals, natural testosterones play acritical role in the normal development and function of the sex organs in malesand the maintenance of spermatogenesis. The actions of androgens are mediatedby the androgen receptor (AR). These receptors have distinct domains for DNAbinding, ligand binding, and transcriptional activation. When androgens bind tothe androgen receptor, a change takes place causing dissociation of theandrogen receptor/DNA complex and results in transcriptional activation.Androgen activation is strongly linked to prostate cancer. The uniquerequirement of androgens to maintain the growth of the tumor and evadeapoptosis is the basis for androgen blocking therapies. Because androgen boundto the androgen receptor is completely enveloped by protein, it is thought thatthe process of ligand binding or unbinding must involve a significantconformational change. Probing the mechanism of ligand binding and release canhave far reaching consequences toward drug design that targets certain types ofprostate cancer.