Dr. Joseph S Erlichman
St. Lawrence University News
Submitted by jerl on Tue, 08/12/2008 - 13:02.
Professor of Biology, R. Sheldon and Virginia Johnson Professor of Science
Courses I teach regularly:
Introduction to Neuroscience
Advanced Neuroscience
Human Anatomy
General Biology
My research interests:
I study glial-neuronal interactions in the brain. Most recently, I am examining the mechanisms that underlie brain injury following stroke using a mouse model. Using cerium oxide nanoparticles we can reduce the tissue damage in the brain following stroke approximately 50%. We are currently working with Clarkson University and Dartmouth Medical School to engineer new nanoparticles that more potent and biologically compatible.
Sample student projects I have supervised:
Erlichman JS, Hewitt A, Damon TL, Hart M, Kurascz J, Li A, Leiter JC. Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis. J Neurosci. 2008 May 7;28(19):4888-96.
Trentini, John F. III, French, L. and J.S. Erlichman. 2006 .The antinociceptive effect of salvinorin A in mice. European Journal of Pharmacology, 545: 129-133.
Hewitt, A, Barrie, R., Graham, M., Bogus, K., Leiter, J,C. and Erlichman, J.S. (2004). Ventilatory effects of gap junction blockade in the RTN in awake rats. American Journal of Physiology 287:R1407-R1418
Trentini, John F. III, Thompson, B., Erlichman, J.S. (2005). The antinociceptive effect of acupressure in rats. American Journal of Chinese Medicine 33(1): 143-150.
Erlichman, J.S., Cook, A., Schwab, M., Budd, T. and Leiter, J.C. (2003). Heterogeneity of pH regulation in medullary glia. American Journal of Physiology, 286(2):R289-302
Nottingham, S., Leiter, J.C., Wages, P.L., Buhay, S. and Erlichman, J.S. (2001) Developmental changes in intracellular pH regulation in medullary glia. American Journal of Physiology, 281:R1940-R1951
Dean, J.B., Ballantyne, D., Cardone, D., Erlichman, J.S. and Solomon, I.C. (2002) Role of gap junctions in CO2 chemoreception and respiratory control. Am J Physiol Lung Cell Mol Physiol. 283(4):L665-70.
Examples of presentations, exhibitions, performances and published work:
Lebedev, M., Linderman, M. and Erlichman, JS. Digital glove handwriting recognition technology is coming, Scientific American Digital. Technology and Innovation, March 31, 2008.
Erlichman JS, Putnam RW, Leiter JC. Glial modulation of CO2 chemosensory excitability in the retrotrapezoid nucleus of rodents. Adv Exp Med Biol. 2008;605:317-21.
Ritucci, N.A., J.S. Erlichman, J.C. Leiter and R.W. Putnam. 2005. Response of membrane potential and intracellular pH to hypercapnia in neurons and astrocytes from rat retrotrapezoid nucleus. Am J Physiol Regul Integr Comp Physiol 289: R851-R861.
Parisian, K., Wages, P., Smith, A., Jarosz, J., Hewitt, A., Leiter, J.C., and Erlichman, J.S. (2004) Ventilatory effects of gap junction blockade in the NTS in awake rats. Journal of Respiration Physiology and Neurobiology 142:127-143
Putnam, Robert W., Susan C. Conrad, M.J. Gdovin, Joseph S. Erlichman and J.C. Leiter. 2005. Neonatal maturation of the hypercapnic ventilatory response and central neural CO2 chemosensitivity. Resp. Physiol. Neurobiol. 149: 165-179.