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Development of a Pilot Scale Process for the Anti-Alzheimer Drug (−)-Galanthamine Using Large-Scale Phenolic Oxidative Coupling

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Development of a Pilot Scale Process for the Anti-Alzheimer Drug (−)-Galanthamine Using Large-Scale Phenolic Oxidative Coupling and Crystallisation-Induced Chiral Conversion
Bernhard Küenburg,†, Laszlo Czollner,†,§, Johannes Fröhlich,*,‡,‖ and, and Ulrich Jordis*,‡,
Organic Process Research & Development 1999 3 (6), 425-431