Dr. Samantha Glazier
Guest Researcher, Chalmers University of Technology, 2009
Keck Teaching and Research Fellow, Bryn Mawr College, 2004
Ph.D. Cornell University, Physical Chemistry, 2001
M.S. Cornell University, Physical Chemistry, 1998
B.S. Western Washington University, Chemistry, 1996
B.A. Western Washington University, Women Studies, 1996
My research seeks to distinguish features of chemical structure that control how drug molecules interact with DNA. Molecules that become threaded through the helix, thereby distorting DNA shape, can inhibit further replication and are of particular interest. Students in my lab make ruthenium based molecules that intercalate between the base pairs inside the double helix of DNA. Exactly how the ruthenium molecules initially approach DNA, become inserted and eventually exist in equilibrium as a free and bound molecule is studied using synthesis and spectrocopic tools.